Zilos-H Tablet contains a combination of Losartan 50mg and Hydrochlorothiazide 12.5mg, used primarily for the management of hypertension. Losartan is an angiotensin II receptor antagonist that works by blocking the binding of angiotensin II to the AT1 receptor, thereby causing vasodilation and reducing blood pressure. Hydrochlorothiazide is a thiazide diuretic that promotes the excretion of sodium and water by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys, contributing to a reduction in blood volume and peripheral resistance. The combination of these two agents provides complementary mechanisms to achieve effective blood pressure control in patients who require more than one antihypertensive agent. Zilos-H is indicated for patients whose blood pressure is not adequately controlled with monotherapy. It is important to monitor electrolyte levels, renal function, and blood pressure regularly during treatment. Contraindications include hypersensitivity to either component, anuria, and severe renal or hepatic impairment. Common adverse effects may include dizziness, hypotension, hyperkalemia, and electrolyte imbalance. Patients should be advised to maintain adequate hydration and report any signs of adverse reactions promptly. Zilos-H should be used under medical supervision with appropriate dose adjustments based on therapeutic response and tolerability.