Zfen-SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac (100 mg), Paracetamol (325 mg), and Serratiopeptidase (15 mg). Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol provides effective analgesia and antipyresis through central inhibition of prostaglandin synthesis, complementing the peripheral action of Aceclofenac. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and inflammation, enhancing tissue healing. This combination is indicated for the management of acute and chronic musculoskeletal pain, osteoarthritis, rheumatoid arthritis, postoperative inflammation, and soft tissue injuries. Zfen-SP Tablet offers synergistic pain relief and inflammation control, improving patient comfort and mobility. It should be administered as prescribed, with caution in patients with gastrointestinal ulcers, hepatic or renal impairment, and hypersensitivity to NSAIDs. Monitoring for adverse effects such as gastrointestinal discomfort, allergic reactions, or altered liver function is recommended. Overall, Zfen-SP Tablet is an effective therapeutic option for managing inflammatory pain conditions, providing multimodal analgesic benefits through its combined pharmacological actions.