Zeromac-SP Tablet is a combination analgesic formulation containing Aceclofenac (100mg), Paracetamol (325mg), and Serratiopeptidase (15mg), designed for the management of pain and inflammation associated with musculoskeletal disorders. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts its effect by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis responsible for inflammation and pain. Paracetamol provides analgesic and antipyretic effects through central inhibition of prostaglandin synthesis, complementing the anti-inflammatory action of Aceclofenac. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and tissue repair. This combination is particularly effective in conditions such as osteoarthritis, rheumatoid arthritis, postoperative pain, and soft tissue injuries. Zeromac-SP Tablet offers rapid relief from pain, swelling, and stiffness, improving patient mobility and quality of life. It should be used under medical supervision, considering contraindications such as hypersensitivity to NSAIDs, active gastrointestinal ulcers, or bleeding disorders. Caution is advised in patients with hepatic, renal, or cardiovascular impairment. The recommended dosage and duration of therapy should be adhered to, minimizing potential adverse effects such as gastrointestinal discomfort, allergic reactions, or hepatic enzyme alterations.