Zerodol-S Tablet is a combination medication containing Aceclofenac 100mg and Serratiopeptidase 15mg, formulated to provide effective relief from pain and inflammation. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Serratiopeptidase is a proteolytic enzyme that facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and swelling. This synergistic combination is commonly prescribed for the management of musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and soft tissue injuries including sprains, strains, and post-operative inflammation. Zerodol-S Tablet provides rapid analgesic effects while enhancing tissue repair and reducing inflammatory exudates. It is generally well-tolerated but should be used with caution in patients with a history of gastrointestinal ulcers, bleeding disorders, or hypersensitivity to NSAIDs. The medication is contraindicated during pregnancy and lactation unless specifically advised by a healthcare professional. Dosage and duration of therapy should be individualized based on clinical response and patient tolerance. Patients are advised to take Zerodol-S Tablet with food to minimize gastrointestinal discomfort and to consult their physician if symptoms persist or worsen.