Zenofenac-SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 15 mg. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory, analgesic, and antipyretic effects by selectively inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol contributes to analgesic and antipyretic actions through central inhibition of prostaglandin synthesis, enhancing pain relief and fever reduction. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and inflammation, improving tissue healing and reducing pain. This synergistic combination is indicated for the management of acute and chronic musculoskeletal disorders, osteoarthritis, rheumatoid arthritis, postoperative pain, dental pain, and soft tissue injuries. Zenofenac-SP provides effective relief from pain and inflammation while promoting faster recovery. It is generally well-tolerated; however, caution is advised in patients with gastrointestinal ulcers, hepatic or renal impairment, and hypersensitivity to NSAIDs. The medication should be used under medical supervision, adhering to prescribed dosages to minimize adverse effects such as gastrointestinal discomfort, allergic reactions, or potential drug interactions. Zenofenac-SP Tablet offers a comprehensive therapeutic approach to pain and inflammation management in clinical practice.