Zenac SP Tablet is a combination analgesic formulation containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 15 mg, designed to provide effective relief from pain and inflammation. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), acts by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Paracetamol, an analgesic and antipyretic agent, enhances pain relief and helps in reducing fever by acting centrally on the hypothalamic heat-regulating center. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and swelling, improving tissue healing. This combination is particularly beneficial in managing musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, and soft tissue injuries, including sprains and strains. Zenac SP Tablet offers a synergistic approach by addressing pain, inflammation, and swelling concurrently, leading to improved patient outcomes. It should be used under medical supervision, especially in patients with a history of gastrointestinal ulcers, renal or hepatic impairment, or hypersensitivity to NSAIDs. The dosage and duration of therapy should be tailored to individual patient needs to maximize efficacy while minimizing adverse effects.