Zegal M Tablet SR is a sustained-release formulation combining Methylcobalamin 1500 mcg and Pregabalin 75 mg, designed for the management of neuropathic pain and associated neurological conditions. Methylcobalamin, an active form of vitamin B12, plays a crucial role in nerve regeneration and repair, supporting the maintenance of healthy nerve function and promoting myelin sheath synthesis. Pregabalin, an anticonvulsant and analgesic agent, modulates calcium channel activity in the central nervous system, thereby reducing the release of excitatory neurotransmitters involved in pain signaling. The synergistic action of these components provides effective relief from neuropathic pain, diabetic neuropathy, postherpetic neuralgia, and other peripheral neuropathies. Zegal M Tablet SR offers the advantage of sustained drug release, ensuring prolonged therapeutic effects with improved patient compliance. It is indicated for patients requiring both neurotrophic support and neuropathic pain management. The medication should be used under medical supervision, with dosage adjustments based on clinical response and tolerability. Common side effects may include dizziness, somnolence, and gastrointestinal disturbances. Caution is advised in patients with renal impairment, and it is contraindicated in individuals with known hypersensitivity to its components. Regular monitoring is recommended to optimize therapeutic outcomes and minimize adverse effects.