Zalex F 10 Tablet is a combination pharmaceutical formulation containing Fluoxetine 20mg and Olanzapine 10mg, indicated primarily for the treatment of major depressive disorder with psychotic features, bipolar disorder, and treatment-resistant depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), functions by increasing serotonin levels in the brain, thereby improving mood and alleviating depressive symptoms. Olanzapine, an atypical antipsychotic, acts by modulating various neurotransmitter receptors, including dopamine and serotonin receptors, which helps in managing psychotic symptoms and mood stabilization. The synergistic effect of these two active ingredients makes Zalex F 10 effective in addressing both the affective and psychotic components of complex psychiatric conditions. It is prescribed under medical supervision, with dosage tailored to individual patient needs based on clinical response and tolerability. Common side effects may include sedation, weight gain, dry mouth, and gastrointestinal disturbances. Caution is advised in patients with a history of cardiovascular disease, diabetes, or seizure disorders. Regular monitoring of metabolic parameters and mental status is recommended during therapy. Zalex F 10 should not be discontinued abruptly to avoid withdrawal symptoms. It is contraindicated in patients with hypersensitivity to either component and should be used cautiously during pregnancy and lactation.