Z-SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac (100mg), Paracetamol (325mg), and Serratiopeptidase (15mg). Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), provides effective relief from pain and inflammation by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol acts centrally to alleviate pain and reduce fever through inhibition of the prostaglandin synthesis pathway in the central nervous system. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and inflammation. The synergistic combination of these agents makes Z-SP Tablet suitable for managing acute and chronic musculoskeletal conditions such as arthritis, tendonitis, bursitis, and postoperative pain. It is also indicated for soft tissue injuries and dental pain where inflammation and swelling are prominent. The medication should be used under medical supervision, with caution advised in patients with a history of gastrointestinal ulcers, hepatic or renal impairment, or hypersensitivity to NSAIDs. Regular monitoring is recommended during prolonged therapy. Z-SP Tablet offers a balanced approach to pain management by targeting multiple pathways involved in inflammation and nociception, thereby improving patient comfort and functional recovery.