Xetomed 90 Tablet contains Etoricoxib 90 mg, a selective cyclooxygenase-2 (COX-2) inhibitor used primarily for the management of pain and inflammation associated with various musculoskeletal and inflammatory conditions. Etoricoxib exerts its therapeutic effect by selectively inhibiting the COX-2 enzyme, thereby reducing the synthesis of prostaglandins involved in pain and inflammatory processes, while sparing COX-1, which helps minimize gastrointestinal adverse effects commonly seen with non-selective NSAIDs. Xetomed 90 is indicated for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis, providing effective relief from pain, swelling, and stiffness. It is also utilized in managing chronic musculoskeletal pain and postoperative pain. The recommended dosage should be individualized based on the patient’s clinical condition and response to therapy, with caution advised in patients with cardiovascular risk factors, renal or hepatic impairment. Common side effects may include headache, dizziness, hypertension, and gastrointestinal discomfort. Due to its potential cardiovascular risks, Etoricoxib should be prescribed at the lowest effective dose for the shortest duration necessary. Xetomed 90 should be used under medical supervision, with regular monitoring for adverse reactions and contraindications, especially in patients with pre-existing cardiovascular or gastrointestinal disorders.