Xeplonac-SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac (100mg), Paracetamol (325mg), and Serratiopeptidase (15mg). Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol contributes to analgesia and antipyresis through central inhibition of prostaglandin synthesis. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of inflammation and edema. This combination is indicated for the management of pain and inflammation associated with musculoskeletal disorders, osteoarthritis, rheumatoid arthritis, dental pain, postoperative inflammation, and soft tissue injuries. Xeplonac-SP Tablet provides effective symptomatic relief by targeting multiple pathways involved in pain and inflammation, enhancing patient comfort and mobility. It is generally well-tolerated; however, caution is advised in patients with gastrointestinal ulcers, hepatic or renal impairment, and hypersensitivity to NSAIDs or any component of the formulation. The dosage and duration of therapy should be individualized based on clinical response and patient tolerance. Consultation with a healthcare professional is recommended prior to use to ensure safety and efficacy.