Wegalin-Plus Tablet SR is a sustained-release formulation combining Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated conditions. Pregabalin, a gabapentinoid, modulates calcium channels to reduce neuronal excitability, thereby alleviating neuropathic pain and improving sleep quality. Nortriptyline, a tricyclic antidepressant, enhances noradrenergic and serotonergic neurotransmission, contributing to analgesic effects and mood stabilization in chronic pain states. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair, promoting recovery in peripheral neuropathies. The sustained-release mechanism ensures prolonged therapeutic plasma concentrations, enhancing patient compliance and minimizing dosing frequency. Wegalin-Plus is indicated for diabetic neuropathy, postherpetic neuralgia, and other peripheral neuropathic pain syndromes. It should be used under medical supervision, with dosage adjustments based on clinical response and tolerability. Common adverse effects may include dizziness, somnolence, dry mouth, and gastrointestinal disturbances. Caution is advised in patients with renal impairment, cardiovascular disorders, or a history of seizures. Concomitant use with CNS depressants requires careful monitoring. Wegalin-Plus Tablet SR offers a multimodal approach to neuropathic pain management, combining analgesic, antidepressant, and neurotrophic actions in a single, convenient dosage form.