Osteofed-GM Tablet is a combination pharmaceutical formulation containing Diacerein (50mg), Glucosamine Sulfate Potassium Chloride (750mg), and Methyl Sulfonyl Methane (MSM) (250mg), designed to support joint health and alleviate symptoms associated with osteoarthritis. Diacerein, an anthraquinone derivative, exhibits anti-inflammatory and chondroprotective properties by inhibiting interleukin-1 beta, thereby reducing cartilage degradation and improving joint function. Glucosamine Sulfate Potassium Chloride serves as a vital substrate for the biosynthesis of glycosaminoglycans and proteoglycans, essential components of cartilage matrix, promoting repair and regeneration of damaged cartilage tissue. Methyl Sulfonyl Methane, a naturally occurring organosulfur compound, contributes to the reduction of oxidative stress and inflammation, supporting connective tissue integrity and joint flexibility. The synergistic action of these active ingredients helps in reducing pain, swelling, and stiffness in affected joints, enhancing mobility and quality of life in patients with osteoarthritis. Osteofed-GM is indicated for the management of mild to moderate osteoarthritis of the knee and other joints. It should be used under medical supervision, with caution in patients with known hypersensitivity to any component or pre-existing gastrointestinal conditions. Regular monitoring and adherence to prescribed dosage are essential to maximize therapeutic benefits while minimizing potential adverse effects.