Orthosenz Ointment is a topical formulation combining Capsaicin (0.025% w/w), Diclofenac (4% w/w), Gabapentin (8% w/w), and Methyl Salicylate (5% w/w) designed for the management of musculoskeletal pain and neuropathic discomfort. Capsaicin acts by depleting substance P, thereby reducing pain signal transmission. Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), provides anti-inflammatory and analgesic effects by inhibiting cyclooxygenase enzymes, reducing prostaglandin synthesis. Gabapentin, an anticonvulsant with analgesic properties, modulates calcium channels to alleviate neuropathic pain. Methyl Salicylate serves as a counterirritant, producing a warming sensation that helps distract from underlying pain. The combination of these active ingredients offers a multimodal approach to pain relief, targeting inflammation, neuropathic pain, and providing symptomatic comfort. Orthosenz Ointment is indicated for conditions such as osteoarthritis, rheumatoid arthritis, neuropathic pain syndromes, and soft tissue injuries. It should be applied topically to the affected area, avoiding broken or irritated skin. Use with caution in patients with hypersensitivity to salicylates or NSAIDs. Common adverse effects may include local skin irritation or burning sensation. Consult a healthcare professional before use, especially in pregnant or lactating women and patients with pre-existing medical conditions.