Orthodex Gel is a topical formulation designed for the relief of joint, shoulder, and muscle pain. It contains Diclofenac (1.16% w/w), a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes, thereby reducing inflammation and alleviating pain. The gel is further enhanced with Oleum Lini (3% w/w), which possesses anti-inflammatory and skin-conditioning properties, supporting tissue repair. Methyl Salicylate (10% w/w) acts as a counterirritant, producing a warming sensation that helps distract from deeper musculoskeletal pain. Benzyl Alcohol (1% w/w) serves as a mild local anesthetic and preservative, contributing to the product’s efficacy and stability. Menthol (5% w/w) provides a cooling effect through activation of TRPM8 receptors, offering symptomatic relief and improving blood circulation in the affected area. Orthodex Gel is indicated for the symptomatic treatment of pain associated with osteoarthritis, rheumatoid arthritis, sprains, strains, and other musculoskeletal disorders. It is intended for external use only and should be applied to the affected area with gentle massage, avoiding broken or irritated skin. Patients should adhere to recommended dosage instructions and consult healthcare professionals if symptoms persist or worsen. Orthodex Gel offers a multi-mechanistic approach to pain management, combining anti-inflammatory, analgesic, and counterirritant effects for effective relief.