Ornoderm RF Cream is a topical formulation combining Miconazole (2% w/w), Mometasone (0.1% w/w), and Nadifloxacin (1% w/w), designed for the effective management of mixed fungal and bacterial skin infections accompanied by inflammatory conditions. Miconazole, an imidazole antifungal agent, inhibits the synthesis of ergosterol, an essential component of fungal cell membranes, thereby exerting broad-spectrum antifungal activity against dermatophytes, yeasts, and molds. Mometasone furoate, a potent corticosteroid, provides anti-inflammatory, antipruritic, and vasoconstrictive effects, reducing erythema, swelling, and discomfort associated with dermatoses. Nadifloxacin, a fluoroquinolone antibiotic, targets bacterial DNA gyrase and topoisomerase IV enzymes, effectively inhibiting bacterial replication and addressing secondary bacterial infections often complicating fungal dermatoses. The combination therapy in Ornoderm RF Cream offers a synergistic approach, facilitating rapid symptom relief and infection control. It is indicated for the treatment of inflammatory dermatoses with mixed infections such as tinea corporis, tinea cruris, and other superficial fungal infections complicated by bacterial involvement and inflammation. The cream should be applied topically as directed by a healthcare professional, avoiding prolonged use to minimize potential corticosteroid-related adverse effects. Caution is advised in patients with known hypersensitivity to any component.