Olay Plus Tablet contains a combination of Fluoxetine 20mg and Olanzapine 5mg, formulated for the treatment of major depressive disorder with psychotic features and treatment-resistant depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), works by increasing serotonin levels in the brain, thereby improving mood, sleep, appetite, and energy levels while reducing anxiety and depressive symptoms. Olanzapine, an atypical antipsychotic, modulates the activity of dopamine and serotonin receptors, helping to alleviate psychotic symptoms such as hallucinations, delusions, and mood disturbances. The combination of these agents provides a synergistic effect, addressing both the depressive and psychotic components of the disorder. Olay Plus is indicated for patients who have not responded adequately to antidepressant therapy alone. It should be administered under strict medical supervision, with dosage adjustments based on clinical response and tolerability. Common side effects may include weight gain, sedation, dry mouth, dizziness, and gastrointestinal disturbances. Caution is advised in patients with a history of cardiovascular disease, diabetes, or seizures. Regular monitoring of metabolic parameters and mental status is recommended during treatment. Olay Plus should not be discontinued abruptly to avoid withdrawal symptoms.