Olanex F Tablet is a combination medication containing Fluoxetine 20 mg and Olanzapine 5 mg, primarily indicated for the treatment of depressive episodes associated with bipolar disorder and treatment-resistant depression. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), functions by increasing serotonin levels in the brain, thereby improving mood and alleviating symptoms of depression. Olanzapine, an atypical antipsychotic, modulates various neurotransmitter receptors, including dopamine and serotonin receptors, contributing to mood stabilization and antipsychotic effects. The synergistic action of these two active ingredients helps manage complex psychiatric conditions by addressing both depressive symptoms and mood swings. Olanex F is typically prescribed when monotherapy with antidepressants or antipsychotics is insufficient. It should be used under strict medical supervision due to potential side effects such as weight gain, sedation, metabolic changes, and extrapyramidal symptoms. Caution is advised in patients with a history of cardiovascular disease, diabetes, or seizures. Regular monitoring of metabolic parameters and mental status is recommended during treatment. Olanex F Tablet is contraindicated in patients with hypersensitivity to its components and should not be abruptly discontinued to avoid withdrawal symptoms. Adherence to prescribed dosage and follow-up consultations are essential for optimal therapeutic outcomes.