Oestrogel is a topical hormone replacement therapy containing estradiol at a concentration of 0.06%, indicated for the treatment of menopausal symptoms associated with estrogen deficiency. This gel formulation allows for transdermal absorption of estradiol, providing a steady and controlled release of the hormone into systemic circulation, thereby mimicking physiological estradiol levels. Oestrogel is primarily prescribed to alleviate vasomotor symptoms such as hot flashes, night sweats, and vaginal dryness, as well as to prevent osteoporosis in postmenopausal women at high risk of fracture. The transdermal route offers advantages over oral estrogen therapy by bypassing first-pass hepatic metabolism, reducing the risk of thromboembolic events and hepatic side effects. The gel is applied once daily to clean, dry, intact skin, typically on the forearm or upper arm, ensuring consistent dosing and improved patient compliance. Contraindications include known or suspected estrogen-dependent neoplasms, unexplained vaginal bleeding, active or history of thromboembolic disorders, and liver dysfunction. Caution is advised in patients with cardiovascular disease, hypertension, or a history of hormone-sensitive cancers. Regular monitoring and periodic evaluation are recommended to assess therapeutic efficacy and detect adverse effects. Oestrogel should be used under medical supervision with individualized dosing tailored to patient needs.