Ocoll-NF Tablet is a combination pharmaceutical formulation containing Nimesulide 100 mg, Phenylephrine 10 mg, Cetirizine 5 mg, and Caffeine 30 mg, designed for the symptomatic relief of allergic and inflammatory conditions accompanied by nasal congestion and headache. Nimesulide, a selective COX-2 inhibitor, provides effective anti-inflammatory, analgesic, and antipyretic effects by reducing prostaglandin synthesis, thereby alleviating pain and inflammation. Phenylephrine acts as a potent alpha-adrenergic agonist, inducing vasoconstriction of nasal mucosal blood vessels, which helps reduce nasal congestion and improve breathing. Cetirizine, a second-generation antihistamine, selectively antagonizes peripheral H1 receptors, mitigating allergic symptoms such as sneezing, rhinorrhea, and itching without causing significant sedation. Caffeine, a central nervous system stimulant, enhances analgesic efficacy and counteracts drowsiness associated with other components, promoting alertness. Ocoll-NF Tablet is indicated for the management of acute allergic rhinitis, sinusitis, and associated headache or fever. It should be used under medical supervision, particularly in patients with hypertension, cardiovascular disorders, or hypersensitivity to any component. The combination offers a multi-modal approach to symptom control, improving patient comfort and quality of life during acute episodes.