Nvtab-OD Tablet is a combination pharmaceutical formulation containing Doxylamine 20 mg and Vitamin B6 (Pyridoxine) 20 mg, primarily indicated for the management of nausea and vomiting, particularly in pregnancy. Doxylamine, a first-generation antihistamine with sedative properties, acts by antagonizing central histamine H1 receptors, thereby reducing vestibular stimulation and nausea. Vitamin B6 plays a crucial role in neurotransmitter synthesis and is essential for normal metabolic functions, contributing to the alleviation of nausea symptoms. The orodispersible tablet (OD) formulation allows for rapid disintegration and absorption in the oral cavity, enhancing patient compliance, especially in those with difficulty swallowing conventional tablets. Nvtab-OD is typically administered once daily or as prescribed by a healthcare professional, with dosing tailored to symptom severity and patient response. It is generally well-tolerated; however, caution is advised in patients with hypersensitivity to antihistamines or pyridoxine. Common adverse effects may include drowsiness, dry mouth, and mild gastrointestinal disturbances. This combination therapy offers a synergistic approach to managing mild to moderate nausea and vomiting, improving quality of life without significant sedation when used appropriately. Clinical monitoring is recommended to ensure efficacy and safety during treatment.