Nurozhil-NT Tablet SR is a sustained-release formulation combining Pregabalin (75 mg), Nortriptyline (10 mg), and Methylcobalamin (1500 mcg), designed for the management of neuropathic pain and associated conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channels to reduce neurotransmitter release, thereby alleviating neuropathic pain and improving nerve function. Nortriptyline, a tricyclic antidepressant, enhances noradrenaline and serotonin levels in the central nervous system, contributing to analgesic effects and mood stabilization in chronic pain syndromes. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair, promoting recovery from peripheral neuropathies. The sustained-release mechanism ensures prolonged therapeutic plasma concentrations, improving patient compliance and minimizing dosing frequency. Nurozhil-NT is indicated for diabetic neuropathy, post-herpetic neuralgia, and other neuropathic pain disorders where multimodal therapy is beneficial. Caution is advised in patients with renal impairment, cardiovascular disease, or a history of seizures. Common adverse effects may include dizziness, dry mouth, somnolence, and gastrointestinal disturbances. This combination therapy offers a comprehensive approach to neuropathic pain management by targeting multiple pathophysiological pathways, enhancing analgesic efficacy while supporting nerve health. It should be prescribed under medical supervision with appropriate monitoring for optimal therapeutic outcomes.