Nurowin-Plus Tablet SR is a sustained-release formulation combining Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated neurological disorders. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channels to inhibit excitatory neurotransmitter release, thereby reducing neuropathic pain and seizures. Nortriptyline, a tricyclic antidepressant, enhances noradrenergic and serotonergic neurotransmission, providing analgesic and mood-stabilizing effects beneficial in chronic pain syndromes. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by promoting myelin sheath synthesis and neuronal function. The sustained-release mechanism ensures prolonged therapeutic plasma concentrations, improving patient compliance and minimizing dosing frequency. Nurowin-Plus is indicated for diabetic neuropathy, post-herpetic neuralgia, peripheral neuropathies, and other neuropathic pain conditions. It may also aid in the treatment of depression and anxiety associated with chronic pain. Caution is advised in patients with renal impairment, cardiac conditions, or those on concomitant CNS depressants. Common adverse effects include dizziness, somnolence, dry mouth, and gastrointestinal disturbances. Nurowin-Plus should be prescribed under medical supervision with appropriate dose adjustments based on clinical response and tolerability.