Nuflam-RB Capsule SR is a combination pharmaceutical formulation containing Aceclofenac 200 mg and Rabeprazole 20 mg, designed for the management of inflammatory conditions accompanied by gastric acid-related disorders. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent analgesic and anti-inflammatory effects by selectively inhibiting cyclooxygenase-2 (COX-2), thereby reducing prostaglandin synthesis responsible for pain and inflammation. Rabeprazole, a proton pump inhibitor (PPI), suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells, providing gastroprotection and reducing the risk of NSAID-induced gastric ulcers. Nuflam-RB Capsule SR is indicated for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other musculoskeletal disorders where inflammation and pain are prominent, particularly in patients at risk of developing NSAID-associated gastrointestinal complications. The sustained-release formulation ensures prolonged therapeutic plasma concentrations, enhancing efficacy and patient compliance by reducing dosing frequency. Caution is advised in patients with known hypersensitivity to NSAIDs or PPIs, history of gastrointestinal bleeding, renal or hepatic impairment, and concurrent use of other medications affecting gastric pH or coagulation. Regular monitoring and adherence to prescribed dosage are essential to minimize adverse effects and optimize clinical outcomes.