Methodol 16 Tablet contains Methylprednisolone 16 mg, a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties. It is primarily indicated for the management of various inflammatory and autoimmune conditions, including rheumatoid arthritis, systemic lupus erythematosus, allergic reactions, asthma exacerbations, and certain dermatologic disorders. Methylprednisolone acts by modulating the immune response, reducing inflammation through inhibition of leukocyte infiltration, suppression of cytokine production, and decreased capillary permeability. Methodol 16 is administered orally and should be used under strict medical supervision, with dosage tailored to the severity of the condition and patient response. It is essential to monitor for potential adverse effects such as hyperglycemia, hypertension, osteoporosis, increased susceptibility to infections, and adrenal suppression, especially with prolonged use. Abrupt discontinuation is contraindicated due to the risk of adrenal insufficiency; gradual tapering is recommended. Caution is advised in patients with diabetes, hypertension, peptic ulcer disease, and psychiatric disorders. Drug interactions may occur with nonsteroidal anti-inflammatory drugs, anticoagulants, and vaccines. Methodol 16 provides effective symptomatic relief and disease control when used appropriately, contributing significantly to the management of inflammatory and immune-mediated diseases. Always consult a healthcare professional before initiating therapy.