Methodec S Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac (100 mg), Paracetamol (325 mg), and Serratiopeptidase (15 mg). Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol provides effective analgesia and antipyresis through central inhibition of prostaglandin synthesis, complementing the action of Aceclofenac. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and inflammation. This synergistic combination is indicated for the management of acute and chronic musculoskeletal pain, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and postoperative inflammatory conditions. Methodec S Tablet is effective in reducing pain, swelling, and stiffness associated with inflammatory disorders, thereby improving patient mobility and quality of life. It should be used under medical supervision, with caution advised in patients with gastrointestinal ulcers, hepatic or renal impairment, and hypersensitivity to NSAIDs. Regular monitoring is recommended during prolonged therapy to detect potential adverse effects such as gastrointestinal irritation, hepatotoxicity, or hypersensitivity reactions. Methodec S Tablet offers a balanced therapeutic approach for inflammatory pain management with enhanced efficacy due to its multi-mechanistic action.