Methico-P Capsule is a combination pharmaceutical formulation containing Methylcobalamin 750 mcg and Pregabalin 75 mg, designed for the management of neuropathic pain and associated neurological conditions. Methylcobalamin, an active form of vitamin B12, plays a crucial role in nerve regeneration and repair by promoting myelin sheath formation and enhancing neuronal function. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, exerts its therapeutic effect by modulating calcium channels in the central nervous system, thereby reducing the release of excitatory neurotransmitters involved in pain signaling. This synergistic combination is particularly effective in treating peripheral neuropathies, diabetic neuropathic pain, postherpetic neuralgia, and other neuropathic disorders. Methico-P Capsule aids in alleviating symptoms such as burning, tingling, numbness, and shooting pain, improving patients’ quality of life. It is generally well-tolerated; however, common adverse effects may include dizziness, somnolence, and gastrointestinal disturbances. Methico-P should be used under medical supervision, with dosage adjustments based on clinical response and tolerability. Caution is advised in patients with renal impairment or hypersensitivity to any component. Overall, Methico-P Capsule offers a comprehensive approach to neuropathic pain management by combining neurotrophic and analgesic properties.