Metacortil-C Cream is a topical formulation combining Mometasone furoate (0.1% w/w), a potent corticosteroid, with Clotrimazole (1% w/w), an effective antifungal agent. This combination is indicated for the treatment of inflammatory dermatoses complicated by or associated with superficial fungal infections. Mometasone exerts anti-inflammatory, antipruritic, and vasoconstrictive effects by inhibiting multiple inflammatory cytokines and mediators, thereby reducing redness, swelling, and itching. Clotrimazole acts by disrupting the fungal cell membrane permeability through inhibition of ergosterol synthesis, effectively targeting dermatophytes, yeasts, and other susceptible fungi. Metacortil-C Cream is primarily used in conditions such as tinea corporis, tinea cruris, and candidiasis where inflammation and fungal infection coexist. The cream should be applied topically to the affected area once or twice daily as directed by a healthcare professional, avoiding contact with eyes and mucous membranes. Treatment duration should be limited to the shortest period necessary to control symptoms to minimize potential corticosteroid-related side effects, including skin atrophy and hypothalamic-pituitary-adrenal axis suppression. Use is contraindicated in viral infections, tuberculosis, and hypersensitivity to any component. Proper diagnosis and adherence to prescribed usage are essential to ensure efficacy and safety.