Melcyl 10mg Tablet contains Methoxsalen, a psoralen derivative used primarily in the treatment of skin disorders such as vitiligo and psoriasis. Methoxsalen acts by intercalating into DNA and, upon exposure to ultraviolet A (UVA) light, forms cross-links that inhibit DNA synthesis and cellular proliferation. This mechanism helps to restore pigmentation in vitiligo and reduce hyperproliferation in psoriatic lesions. Melcyl 10mg is typically administered orally prior to UVA phototherapy sessions, with the timing and dosage carefully adjusted by healthcare professionals to optimize therapeutic outcomes while minimizing adverse effects. The medication requires strict adherence to UVA exposure guidelines to prevent phototoxic reactions. Common side effects may include nausea, headache, dizziness, and photosensitivity. Long-term use necessitates regular monitoring due to the potential risk of phototoxicity and increased susceptibility to skin malignancies. Melcyl 10mg should be used under medical supervision, with contraindications including hypersensitivity to Methoxsalen, pregnancy, and certain hepatic or renal impairments. Patients are advised to avoid excessive sunlight and use protective measures during treatment. This medication represents an effective adjunct in photochemotherapy protocols for select dermatological conditions.