Melanorm-F Cream is a topical formulation containing Hydroquinone (2% w/w), Tretinoin (0.025% w/w), and Fluocinolone acetonide (0.01% w/w), indicated for the treatment of melasma and other hyperpigmentation disorders. Hydroquinone acts as a depigmenting agent by inhibiting tyrosinase, thereby reducing melanin synthesis and promoting skin lightening. Tretinoin, a retinoid, facilitates increased skin cell turnover and enhances the penetration of hydroquinone, contributing to the effective resolution of hyperpigmented lesions. Fluocinolone acetonide, a mild corticosteroid, provides anti-inflammatory effects that help minimize irritation and erythema commonly associated with hydroquinone and tretinoin use. The combination therapy offers a synergistic approach to managing melasma by targeting pigmentation, promoting epidermal renewal, and controlling inflammation. Melanorm-F Cream should be applied once daily at bedtime to the affected areas after cleansing, avoiding contact with eyes and mucous membranes. Patients are advised to use sunscreen and limit sun exposure during treatment to prevent exacerbation of pigmentation. Adverse effects may include mild burning, redness, or peeling; prolonged use should be monitored by a healthcare professional to avoid potential corticosteroid-related side effects. This product is intended for external use only and should be used under medical supervision.