Meftal-Spas Tablet is a combination medication containing Dicyclomine 10 mg and Mefenamic Acid 250 mg, commonly prescribed for the relief of pain associated with gastrointestinal and genitourinary spasms. Dicyclomine is an anticholinergic agent that acts by inhibiting the muscarinic action of acetylcholine on smooth muscles, thereby reducing muscle spasms and cramping in the gastrointestinal tract. Mefenamic Acid, a nonsteroidal anti-inflammatory drug (NSAID), provides analgesic and anti-inflammatory effects by inhibiting cyclooxygenase enzymes, leading to decreased synthesis of prostaglandins responsible for pain and inflammation. This combination is particularly effective in managing conditions such as irritable bowel syndrome, dysmenorrhea, and other spastic disorders where both pain and muscle spasms are present. Meftal-Spas should be administered as per the prescribing physician’s instructions, with caution advised in patients with a history of gastrointestinal ulcers, bleeding disorders, or hypersensitivity to NSAIDs or anticholinergic agents. Common side effects may include dry mouth, dizziness, nausea, and mild gastrointestinal discomfort. It is contraindicated during pregnancy and lactation unless specifically directed by a healthcare professional. Regular monitoring and adherence to dosage guidelines are essential to minimize adverse effects and ensure therapeutic efficacy.