Mecoverge-NT 50 Tablet SR is a combination medication containing Pregabalin 50 mg, Nortriptyline 5 mg, and Methylcobalamin 1500 mcg, formulated for sustained release to provide prolonged therapeutic effects. Pregabalin, an anticonvulsant and neuropathic pain agent, modulates calcium channels to reduce neurotransmitter release, thereby alleviating neuropathic pain and seizures. Nortriptyline, a tricyclic antidepressant, enhances noradrenaline and serotonin activity in the central nervous system, contributing to analgesic effects and mood stabilization. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair, improving nerve function and reducing neuropathy symptoms. This combination is primarily indicated for the management of neuropathic pain associated with diabetic neuropathy, postherpetic neuralgia, and other peripheral neuropathies. The sustained-release formulation ensures steady plasma concentrations, enhancing patient compliance and minimizing side effects. Mecoverge-NT 50 is contraindicated in patients with hypersensitivity to any component, severe renal impairment, or cardiac conduction abnormalities. Common adverse effects may include dizziness, somnolence, dry mouth, and gastrointestinal disturbances. Caution is advised when used concomitantly with CNS depressants or in patients with a history of cardiac arrhythmias. Mecoverge-NT 50 Tablet SR should be used under medical supervision with appropriate dosage adjustments based on clinical response and tolerability.