Mecosule Plus Capsule is a combination pharmaceutical formulation containing Methylcobalamin 750 mcg and Pregabalin 75 mg, designed for the management of neuropathic pain and associated neurological disorders. Methylcobalamin, an active form of vitamin B12, plays a crucial role in nerve regeneration and repair by promoting myelin sheath synthesis and enhancing neuronal function. Pregabalin, an anticonvulsant and analgesic agent, modulates calcium channel activity in the central nervous system, thereby reducing the release of excitatory neurotransmitters and alleviating neuropathic pain symptoms such as burning, tingling, and shooting sensations. This synergistic combination is indicated for diabetic neuropathy, postherpetic neuralgia, radiculopathy, and other peripheral neuropathies. Mecosule Plus Capsule is administered orally, with dosage tailored according to the severity of symptoms and patient response. Common adverse effects may include dizziness, somnolence, gastrointestinal disturbances, and mild allergic reactions; therefore, caution is advised in patients with renal impairment or hypersensitivity to either component. Regular monitoring and consultation with a healthcare professional are recommended to optimize therapeutic outcomes and minimize potential side effects. Mecosule Plus Capsule offers an effective approach to improving nerve function and providing symptomatic relief in neuropathic conditions.