Mecoryl NP 75mg/10mg/1500mcg Tablet SR is a combination pharmaceutical formulation containing Pregabalin 75mg, Nortriptyline 10mg, and Methylcobalamin 1500mcg, designed for the management of neuropathic pain and associated conditions. Pregabalin, an anticonvulsant and analgesic agent, modulates calcium channels to reduce neuronal excitability and alleviate neuropathic pain symptoms. Nortriptyline, a tricyclic antidepressant, enhances noradrenergic and serotonergic neurotransmission, contributing to pain relief and mood stabilization in chronic neuropathic conditions. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair, promoting improved nerve function and reducing neuropathy-related deficits. The sustained-release (SR) formulation ensures a controlled and prolonged release of active ingredients, optimizing therapeutic efficacy while minimizing dosing frequency and potential side effects. Mecoryl NP is indicated for peripheral neuropathy, diabetic neuropathy, post-herpetic neuralgia, and other neuropathic pain syndromes. It should be used under medical supervision with appropriate dose adjustments based on patient response and tolerability. Common adverse effects may include dizziness, dry mouth, sedation, and gastrointestinal disturbances. Caution is advised in patients with renal impairment, cardiovascular disorders, or concomitant CNS depressant use. Overall, Mecoryl NP offers a multimodal approach to neuropathic pain management, combining analgesic, antidepressant, and neurotrophic properties in a single tablet.