Mecocel PG 1500mcg/75mg Tablet is a combination medication containing Methylcobalamin 1500mcg and Pregabalin 75mg, indicated for the management of neuropathic pain and peripheral neuropathy. Methylcobalamin, an active form of vitamin B12, plays a crucial role in nerve regeneration and repair by promoting myelin sheath formation and enhancing nerve conduction. Pregabalin, an anticonvulsant and analgesic agent, modulates calcium channel function in the central nervous system, thereby reducing neuronal excitability and alleviating neuropathic pain symptoms such as burning, tingling, and numbness. This combination is particularly beneficial in diabetic neuropathy, postherpetic neuralgia, and other neuropathic conditions where nerve damage and pain coexist. Mecocel PG is well-tolerated, with common adverse effects including dizziness, somnolence, and gastrointestinal disturbances, which are generally mild and transient. The tablet should be administered as prescribed by a healthcare professional, with dosage adjustments based on clinical response and tolerability. Caution is advised in patients with renal impairment, and it is contraindicated in individuals with known hypersensitivity to either component. Regular monitoring and adherence to prescribed therapy optimize therapeutic outcomes and improve patient quality of life in neuropathic pain management.