ME-Pxl Tablet is a combination pharmaceutical formulation containing Methylcobalamin 1500 mcg and Pregabalin 75 mg, indicated for the management of neuropathic pain and associated neurological disorders. Methylcobalamin, an active form of vitamin B12, plays a crucial role in nerve regeneration and repair by promoting myelin sheath synthesis and enhancing neuronal metabolism. Pregabalin, a gamma-aminobutyric acid (GABA) analog, exerts its therapeutic effect by modulating calcium channel function in the central nervous system, thereby reducing neurotransmitter release and alleviating neuropathic pain symptoms such as burning, shooting pain, and allodynia. ME-Pxl Tablet is commonly prescribed for conditions including diabetic peripheral neuropathy, postherpetic neuralgia, and neuropathic pain secondary to spinal cord injury. The synergistic action of Methylcobalamin and Pregabalin not only provides symptomatic relief but also supports nerve healing and functional recovery. Dosage should be individualized based on patient response and clinical condition, with close monitoring for potential adverse effects such as dizziness, somnolence, gastrointestinal disturbances, and allergic reactions. ME-Pxl Tablet should be used under medical supervision, with caution advised in patients with renal impairment or a history of hypersensitivity to either component. This combination therapy offers an effective approach for comprehensive neuropathic pain management and nerve health restoration.