Masonac-SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 15 mg. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), provides effective relief from pain and inflammation by inhibiting cyclooxygenase enzymes involved in prostaglandin synthesis. Paracetamol acts as an analgesic and antipyretic agent, enhancing pain relief and reducing fever through central inhibition of prostaglandin synthesis. Serratiopeptidase, a proteolytic enzyme, facilitates the reduction of inflammation and edema by breaking down proteinaceous exudates and promoting tissue repair. This combination is particularly beneficial in managing acute musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, postoperative pain, and soft tissue injuries. Masonac-SP Tablet offers synergistic effects, providing rapid and sustained relief from pain, inflammation, and swelling. It is generally well-tolerated; however, caution is advised in patients with a history of gastrointestinal ulcers, bleeding disorders, or hepatic impairment. The medication should be used under medical supervision, adhering to prescribed dosages to minimize potential adverse effects such as gastrointestinal discomfort, allergic reactions, or hepatotoxicity. Masonac-SP Tablet is a valuable therapeutic option for effective multimodal pain management in clinical practice.