Mahanac S Tablet is a combination analgesic formulation containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 15 mg, designed for the effective management of pain and inflammation. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts its therapeutic effect by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Paracetamol provides analgesic and antipyretic effects through central inhibition of prostaglandin synthesis, complementing the action of Aceclofenac. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and swelling, enhancing tissue repair. This combination is indicated for the treatment of musculoskeletal disorders such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and soft tissue injuries including sprains and strains. Mahanac S Tablet offers rapid relief from pain, inflammation, and associated symptoms, improving patient mobility and quality of life. It should be used under medical supervision, considering contraindications such as hypersensitivity to NSAIDs, active peptic ulcer, or bleeding disorders. Caution is advised in patients with hepatic, renal, or cardiovascular impairment. The dosage and duration of therapy should be tailored to individual patient needs to maximize efficacy and minimize adverse effects.