Mahagaba-M OD Tablet SR is a sustained-release formulation combining Methylcobalamin 1500 mcg and Pregabalin 75 mg, designed for the management of neuropathic pain and associated neurological conditions. Methylcobalamin, an active form of vitamin B12, plays a crucial role in nerve regeneration, myelin sheath repair, and overall neuronal health, thereby aiding in the recovery of peripheral neuropathies. Pregabalin, an anticonvulsant and analgesic agent, modulates calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters and effectively alleviating neuropathic pain, including diabetic neuropathy, postherpetic neuralgia, and fibromyalgia. The sustained-release mechanism ensures a steady plasma concentration, enhancing patient compliance through once-daily dosing and minimizing peak-related side effects. Mahagaba-M OD Tablet SR is indicated for patients requiring combined neurotrophic support and neuropathic pain relief. It should be used under medical supervision, with caution in patients with renal impairment or hypersensitivity to its components. Common adverse effects may include dizziness, somnolence, and gastrointestinal disturbances. Regular monitoring and dose adjustments may be necessary based on therapeutic response and tolerability. This combination therapy offers a synergistic approach to managing complex neuropathic conditions, improving quality of life and functional outcomes.