Lysoflam-MR Tablet is a combination medication containing Diclofenac 50 mg and Metaxalone 400 mg, formulated for the effective management of musculoskeletal pain and inflammation. Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), exerts its therapeutic effect by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for pain, inflammation, and swelling. Metaxalone is a centrally acting skeletal muscle relaxant that alleviates muscle spasms by depressing the central nervous system, facilitating improved mobility and comfort. Lysoflam-MR is indicated for the treatment of acute musculoskeletal conditions such as strains, sprains, and back pain, where both inflammation and muscle spasm are present. The combination provides synergistic relief, addressing both pain and muscle stiffness. It is recommended to be used under medical supervision, with caution in patients with a history of gastrointestinal ulcers, hepatic or renal impairment, and cardiovascular disorders. Common adverse effects may include gastrointestinal discomfort, dizziness, and drowsiness. Patients should avoid alcohol and activities requiring mental alertness while on this medication. Dosage and duration should be as prescribed by a healthcare professional to minimize risks and optimize therapeutic outcomes.