Lycegalin Duo 75 Capsule DR is a combination pharmaceutical formulation containing Pregabalin 75 mg and Duloxetine 20 mg, indicated for the management of neuropathic pain and generalized anxiety disorders. Pregabalin, an anticonvulsant and analgesic agent, modulates calcium channels to reduce neurotransmitter release, thereby alleviating neuropathic pain and seizures. Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), enhances central nervous system neurotransmitter activity, contributing to pain relief and mood stabilization. The delayed-release (DR) capsule design ensures optimal absorption and sustained therapeutic effect. Lycegalin Duo 75 is primarily prescribed for patients suffering from diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, and anxiety-related conditions where monotherapy has proven insufficient. The combination therapy offers synergistic benefits by targeting multiple pain pathways and improving patient compliance through reduced pill burden. Common adverse effects may include dizziness, somnolence, dry mouth, nausea, and fatigue; thus, monitoring is advised during treatment initiation. Caution is warranted in patients with hepatic or renal impairment, and gradual dose titration is recommended to minimize side effects. Lycegalin Duo 75 Capsule DR should be used under strict medical supervision, with attention to potential drug interactions and contraindications, to ensure safe and effective management of neuropathic pain and associated disorders.