Lupigest 400 Soft Gelatin Capsule contains Progesterone (Natural Micronized) 400 mg, a vital hormone used primarily in hormone replacement therapy and various gynecological conditions. Progesterone is essential for regulating the menstrual cycle, supporting early pregnancy, and maintaining the uterine lining. This formulation delivers natural micronized progesterone, which enhances bioavailability and mimics endogenous hormone activity more closely than synthetic analogs. Indicated for the treatment of progesterone deficiency, Lupigest 400 is commonly prescribed for luteal phase support in assisted reproductive technology (ART), prevention of threatened miscarriage, and management of secondary amenorrhea. It may also be utilized in hormone replacement therapy to counteract the proliferative effects of estrogen on the endometrium in postmenopausal women. The soft gelatin capsule ensures ease of administration and optimal absorption through the gastrointestinal tract. Patients should follow prescribed dosing regimens and consult healthcare providers regarding contraindications such as known hypersensitivity to progesterone, active thromboembolic disorders, or hormone-sensitive malignancies. Common adverse effects may include dizziness, headache, breast tenderness, and gastrointestinal discomfort. Lupigest 400 should be used under strict medical supervision to ensure therapeutic efficacy and minimize potential risks associated with hormone therapy.