Lupiflex 4 Tablet is a combination medication containing Ketoprofen 50 mg and Thiocolchicoside 4 mg, designed for the management of musculoskeletal pain and inflammation. Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), exerts its therapeutic effect by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for pain, inflammation, and fever. Thiocolchicoside is a muscle relaxant with antispasmodic properties that acts as a selective antagonist of gamma-aminobutyric acid (GABA) and glycine receptors in the central nervous system, leading to relief from muscle spasms and stiffness. The combination of these two agents provides synergistic benefits in conditions such as acute musculoskeletal disorders, including strains, sprains, lower back pain, and other painful muscle spasms. Lupiflex 4 Tablet is typically prescribed for short-term use due to potential side effects associated with NSAIDs and muscle relaxants. Common adverse effects may include gastrointestinal discomfort, dizziness, and allergic reactions. It is contraindicated in patients with hypersensitivity to either component, active gastrointestinal bleeding, severe hepatic or renal impairment, and during pregnancy or lactation without medical supervision. Patients should use Lupiflex 4 Tablet under medical guidance, adhering to recommended dosages to minimize risks and optimize therapeutic outcomes.