Lubry-GM Tablet is a combination pharmaceutical formulation containing Glucosamine sulfate 750 mg, Diacerein 50 mg, and Methyl Sulfonyl Methane (MSM) 250 mg, designed to support joint health and alleviate symptoms associated with osteoarthritis and other degenerative joint disorders. Glucosamine is a naturally occurring amino sugar that contributes to the synthesis of glycosaminoglycans, essential components of cartilage, thereby promoting cartilage repair and maintenance. Diacerein, an anthraquinone derivative, exhibits anti-inflammatory and chondroprotective properties by inhibiting interleukin-1 beta (IL-1β), a key mediator in cartilage degradation and inflammation. Methyl Sulfonyl Methane serves as a sulfur donor, facilitating the synthesis of connective tissue and reducing oxidative stress within joint structures. The synergistic action of these agents helps reduce joint pain, stiffness, and inflammation, improving mobility and quality of life in patients with osteoarthritis. Lubry-GM is indicated for symptomatic management of mild to moderate osteoarthritis of the knee and other joints. It should be used under medical supervision, with caution in patients with known hypersensitivity to any component, and is contraindicated in severe hepatic or renal impairment. Regular monitoring and adherence to prescribed dosage enhance therapeutic outcomes while minimizing adverse effects.