Loyzide M 60mg/500mg Tablet XR
Loyzide M 60mg/500mg Tablet XR
Gliclazide (60mg) + Metformin (500mg)
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About This Medicine
Product description & overview
Loyzide M 60mg/500mg Tablet XR is an extended-release oral medication combining Gliclazide 60mg and Metformin 500mg, indicated for the management of type 2 diabetes mellitus. Gliclazide, a sulfonylurea class agent, functions by stimulating pancreatic beta cells to enhance insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production and increasing peripheral insulin sensitivity, contributing to better glucose uptake and utilization. The extended-release formulation allows for sustained drug release, promoting stable plasma concentrations and reducing dosing frequency, which may improve patient compliance. Loyzide M is typically prescribed as an adjunct to diet and exercise when monotherapy with either agent is insufficient to achieve target glycemic levels. It is essential to monitor blood glucose regularly to adjust dosage appropriately and minimize the risk of hypoglycemia, particularly due to the sulfonylurea component. Caution is advised in patients with renal impairment, hepatic dysfunction, or conditions predisposing to lactic acidosis. Common adverse effects include gastrointestinal disturbances and hypoglycemia. This combination therapy offers a complementary mechanism of action, providing effective glycemic control in patients with type 2 diabetes.
Active composition
Metformin 500 mg
+1 more active ingredient
About Metformin
Metformin is an oral antihyperglycemic agent used to manage type 2 diabetes mellitus. It works by decreasing glucose production in the liver and improving insulin sensitivity. Metformin is effective in controlling blood sugar levels and preventing diabetes-related complications. In summary, Metformin is vital for managing type 2 diabetes.
How It Works
Metformin reduces hepatic glucose production and enhances peripheral insulin sensitivity, lowering blood glucose levels.
All Active Ingredients
Gliclazide
Gliclazide stimulates insulin secretion from pancreatic beta cells and enhances insulin sensitivity in peripheral tissues.
Dosage & How to Use
Dosage information not available. Please consult your doctor or pharmacist.
Safety Advice
Important precautions
Side Effect Occurrence
Based on clinical trials and patient reports.
Overall Tolerance
Most patients tolerate well
Common Side Effects
Safety Advice
Alcohol
It is unsafe to consume alcohol with Loyzide M 60mg/500mg Tablet XR.
High Risk
Pregnancy
Loyzide M 60mg/500mg Tablet XR is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Medical Advice
Driving
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Exercise Caution
Liver
Loyzide M 60mg/500mg Tablet XR should be used with caution in patients with liver disease. Dose adjustment of Loyzide M 60mg/500mg Tablet XR may be needed. Please consult your doctor. Loyzide M 60mg/500mg Tablet XR is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
Regular Checkup
Breastfeeding
Loyzide M 60mg/500mg Tablet XR is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Kidney
Loyzide M 60mg/500mg Tablet XR should be used with caution in patients with kidney disease. Dose adjustment of Loyzide M 60mg/500mg Tablet XR may be needed. Please consult your doctor. Use of Loyzide M 60mg/500mg Tablet XR is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Regular Checkup
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