Loyfenac-R 200mg/20mg Capsule SR is a combination medication containing Aceclofenac 200mg and Rabeprazole 20mg, formulated for sustained release to provide effective management of pain and inflammation associated with musculoskeletal disorders while protecting the gastrointestinal mucosa. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory, analgesic, and antipyretic effects by selectively inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing prostaglandin synthesis responsible for pain and inflammation. Rabeprazole, a proton pump inhibitor (PPI), suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells, reducing the risk of NSAID-induced gastric ulcers and dyspepsia. This combination is particularly beneficial for patients requiring long-term NSAID therapy who are at increased risk of gastrointestinal complications. Loyfenac-R is indicated for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other inflammatory conditions where symptomatic relief and gastroprotection are necessary. The sustained-release formulation ensures prolonged therapeutic effects with improved patient compliance. It is recommended to use this medication under medical supervision, considering contraindications such as hypersensitivity to NSAIDs or PPIs, active peptic ulcer, severe hepatic or renal impairment, and pregnancy. Monitoring for adverse effects including gastrointestinal discomfort, renal function alterations, and hypersensitivity reactions is advised during therapy.