Lowsterol-F Tablet is a combination lipid-lowering medication containing Fenofibrate 160 mg and Rosuvastatin 10 mg, indicated for the management of dyslipidemia and mixed hyperlipidemia. Fenofibrate, a fibric acid derivative, primarily reduces triglyceride levels and increases high-density lipoprotein cholesterol (HDL-C) by activating peroxisome proliferator-activated receptor alpha (PPARα), which enhances lipolysis and elimination of triglyceride-rich particles. Rosuvastatin, a potent HMG-CoA reductase inhibitor, decreases low-density lipoprotein cholesterol (LDL-C) by inhibiting the rate-limiting enzyme in cholesterol biosynthesis, thereby reducing total cholesterol and LDL-C levels. The combination therapy is particularly beneficial for patients who require substantial reductions in LDL-C and triglycerides simultaneously, offering improved lipid profile management compared to monotherapy. Lowsterol-F is prescribed as an adjunct to diet and lifestyle modifications, including exercise and weight control, to reduce the risk of cardiovascular events such as myocardial infarction and stroke in patients with hypercholesterolemia or mixed dyslipidemia. Caution is advised in patients with hepatic or renal impairment, and regular monitoring of liver enzymes and creatine kinase levels is recommended to detect potential adverse effects such as hepatotoxicity or myopathy. This medication should be used under strict medical supervision.