Locren Capsule SR

Locren Capsule SR
Aceclofenac (200mg) + Rabeprazole (20mg)
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About This Medicine
Product description & overview
Locren Capsule SR is a sustained-release formulation combining Aceclofenac 200mg and Rabeprazole 20mg, designed to provide effective management of inflammatory conditions accompanied by gastric acid-related symptoms. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent analgesic and anti-inflammatory effects by selectively inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis responsible for pain and inflammation. Rabeprazole, a proton pump inhibitor, suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells, providing gastroprotection against NSAID-induced gastric mucosal damage. This combination is particularly beneficial in patients requiring long-term NSAID therapy who are at risk of developing gastrointestinal complications such as gastritis or peptic ulcers. Locren Capsule SR is indicated for conditions including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other musculoskeletal disorders requiring anti-inflammatory treatment while minimizing gastrointestinal side effects. The sustained-release mechanism ensures prolonged therapeutic plasma concentrations, enhancing patient compliance and symptom control. It is recommended to administer Locren Capsule SR as prescribed by a healthcare professional, with caution advised in patients with known hypersensitivity to NSAIDs or proton pump inhibitors, and in those with pre-existing hepatic, renal, or cardiac conditions. Regular monitoring is advised during prolonged therapy.
Active composition
Aceclofenac 200 mg
+1 more active ingredient
About Aceclofenac
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to alleviate pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It works by blocking the COX enzymes responsible for producing prostaglandins, which mediate pain and inflammation. Aceclofenac is effective in reducing symptoms and improving joint function. In summary, Aceclofenac is beneficial in managing pain and inflammation in various arthritic conditions.
How It Works
Aceclofenac inhibits COX-1 and COX-2 enzymes, leading to decreased synthesis of prostaglandins, which are responsible for pain and inflammation.
All Active Ingredients
Rabeprazole
Rabeprazole irreversibly inhibits the H+/K+ ATPase enzyme in gastric parietal cells, reducing gastric acid secretion.
Dosage & How to Use
Dosage information not available. Please consult your doctor or pharmacist.
Safety Advice
Important precautions
Side Effect Occurrence
Based on clinical trials and patient reports.
Overall Tolerance
Most patients tolerate well
Common Side Effects
Safety Advice
Alcohol
It is unsafe to consume alcohol with Locren Capsule SR.
High Risk
Pregnancy
Locren Capsule SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Medical Advice
Driving
Locren Capsule SR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Exercise Caution
Liver
Locren Capsule SR should be used with caution in patients with liver disease. Dose adjustment of Locren Capsule SR may be needed. Please consult your doctor.
Regular Checkup
Breastfeeding
Information regarding the use of Locren Capsule SR during breastfeeding is not available. Please consult your doctor.
Consult Doctor
Kidney
Locren Capsule SR should be used with caution in patients with kidney disease. Dose adjustment of Locren Capsule SR may be needed. Please consult your doctor. Use of Locren Capsule SR is not recommended in patients with severe kidney disease.
Regular Checkup
Customer Reviews
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