Listril Plus Tablet contains a combination of Lisinopril 5mg and Hydrochlorothiazide 12.5mg, formulated for the management of hypertension. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that works by relaxing blood vessels, thereby reducing blood pressure and improving blood flow. Hydrochlorothiazide is a thiazide diuretic that helps eliminate excess salt and water from the body through increased urine output, further aiding in blood pressure reduction. The synergistic action of these two agents provides effective control of high blood pressure, reducing the risk of cardiovascular events such as stroke, heart attack, and kidney damage. Listril Plus is indicated for patients who require combination therapy due to inadequate blood pressure control with monotherapy. It is important to monitor electrolyte levels, renal function, and blood pressure regularly during treatment to avoid potential adverse effects such as hypotension, hyperkalemia, or electrolyte imbalance. Patients should inform their healthcare provider of any pre-existing conditions, including kidney or liver impairment, and any concurrent medications to prevent drug interactions. Listril Plus should be used under medical supervision, adhering strictly to prescribed dosages to achieve optimal therapeutic outcomes in hypertension management.