Leucorin Tablet contains Calcium Leucovorin 15 mg, a pharmacologically active form of folinic acid used primarily as a chemoprotective agent and folate supplement. It is indicated for the prevention and treatment of folic acid deficiency and its associated megaloblastic anemia, particularly in patients undergoing methotrexate therapy, where it serves to reduce the toxic effects of folate antagonists. Calcium Leucovorin acts by bypassing the dihydrofolate reductase blockade, thereby replenishing the active folate pool necessary for DNA synthesis and cellular repair. Additionally, Leucorin is employed as an adjuvant in cancer chemotherapy protocols to enhance the efficacy of fluorouracil and other antimetabolite agents by modulating their cytotoxic effects. The tablet formulation ensures precise dosing and ease of administration. Leucorin should be used under strict medical supervision, with dosage adjustments based on the clinical condition and response. Common adverse effects are generally mild and may include gastrointestinal discomfort or allergic reactions. Contraindications include hypersensitivity to folinic acid or related compounds. Caution is advised in patients with renal impairment. Overall, Leucorin Tablet is an essential therapeutic agent in oncology and hematology for managing folate-related deficiencies and mitigating chemotherapy-induced toxicity.